Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrp8tm2.1Her
Name:	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 2.1, Joachim Herz
MGI ID:	MGI:3603433
Synonyms:	Apoer2[ex19], Apoer2[long], ex19
Gene:	Lrp8  Location: Chr4:107659337-107734037 bp, + strand  Genetic Position: Chr4, 50.18 cM, cytoband C7
Alliance:	Lrp8tm2.1Her page

Germline Transmission:	Earliest citation of germline transmission: J:100988
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Modified isoform(s)) Mutation:    Insertion   Mutation details: A targeting vector containing exons 17-20 and loxP-flanked neomycin cassette encoding the intracellular domain was inserted into the locus such that the locus constitutively expressed the 59 amino acid insert encoded by exon 19. Cre-mediated recombination removed the neomycin cassette. (J:100988)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp8 Mutation:	41 strains or lines available

Original:	J:100988 Beffert U, et al., Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 2005 Aug 18;47(4):567-79
All:	4 reference(s)