Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Socs7tm1Pbro
Name:	suppressor of cytokine signaling 7; targeted mutation 1, Paul B Rothman
MGI ID:	MGI:3603205
Synonyms:	Socs7-
Gene:	Socs7  Location: Chr11:97253261-97289368 bp, + strand  Genetic Position: Chr11, 60.96 cM
Alliance:	Socs7tm1Pbro page

Germline Transmission:	Earliest citation of germline transmission: J:100915
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3-6 were replaced with a neomycin resistance gene. Disruption of the full length transcript was demonstrated in Northern blot of liver, skeletal muscle and testis. Low levels of expression persisted in the testis, suggesting that the testis-specific isoform is not the product of exons deleted in the targeting event. (J:100915)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Socs7 Mutation:	22 strains or lines available

Original:	J:100915 Banks AS, et al., Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest. 2005 Sep;115(9):2462-71
All:	2 reference(s)