Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Etv5tm1Kmm
Name:	ets variant 5; targeted mutation 1, Kenneth M Murphy
MGI ID:	MGI:3589421
Synonyms:	ERM-, Etv5-
Gene:	Etv5  Location: Chr16:22200063-22258320 bp, - strand  Genetic Position: Chr16, 13.3 cM, cytoband B1
Alliance:	Etv5tm1Kmm page

Germline Transmission:	Earliest citation of germline transmission: J:100645
Parent Cell Line:	MC50 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-5, which encode the initiation codon and transcriptional activation domain, were replaced with a floxed neo cassette. Transient cre expression removed the neo in two clones: A7 and E7. Northern blot of brain samples failed to detect full-length transcript. (J:100645)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Etv5 Mutation:	270 strains or lines available

Original:	J:100645 Chen C, et al., ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature. 2005 Aug 18;436(7053):1030-4
All:	13 reference(s)