Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpx1tm1Mgr
Name:	glutathione peroxidase 1; targeted mutation 1, Grant R MacGregor
MGI ID:	MGI:3589261
Synonyms:	Gpx1-
Gene:	Gpx1  Location: Chr9:108216279-108217541 bp, + strand  Genetic Position: Chr9, 59.24 cM, cytoband F1
Alliance:	Gpx1tm1Mgr page

Germline Transmission:	Earliest citation of germline transmission: J:62395
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The two exons were replaced with a PGK-neo cassette. Western blot of mutant brain tissue lysate failed to detect protein. (J:62395)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpx1 Mutation:	19 strains or lines available

Original:	J:62395 Esposito LA, et al., Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic Biol Med. 2000 Mar 1;28(5):754-66
All:	1 reference(s)