Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Apctm1Kk
Name:	APC, WNT signaling pathway regulator; targeted mutation 1, Khashayarsha Khazaie
MGI ID:	MGI:3589207
Synonyms:	Apclox468
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm1Kk page

Germline Transmission:	Earliest citation of germline transmission: J:100461
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted to flank exons 11 and 12. Cre-mediated deletion of these exons would result in the out-of-frame splicing of exon 10 to exon 13 and the generation of a prematurely terminated 468-amino acid protein. This mutant protein would be shorter than most truncated Apc proteins. (J:100461)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:100461 Gounari F, et al., Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005 Aug;6(8):800-9
All:	17 reference(s)