Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sesn2Gt(RRJ141)Byg
Name:	sestrin 2; gene trap RRJ141, BayGenomics
MGI ID:	MGI:3587950
Synonyms:	Sesn2Gt(pGT0Lxf)1Ucd
Gene:	Sesn2  Location: Chr4:132220115-132237767 bp, - strand  Genetic Position: Chr4, 65.45 cM
Alliance:	Sesn2Gt(RRJ141)Byg page

Mutant Cell Line:	RRJ141
Germline Transmission:	Earliest citation of germline transmission: J:139563
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     A gene trap vector inserted into intron 3 of the gene. (J:139563) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select RRJ141 CC326179 (MGI Seq Detail) 5' RACE Chr4:132229875-132237477 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 30 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sesn2 Mutation:	114 strains or lines available

Original:	J:139563 Budanov AV, et al., p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 8;134(3):451-60
All:	19 reference(s)