Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fxyd2tm1Kdr
Name:	FXYD domain-containing ion transport regulator 2; targeted mutation 1, Gerald M Kidder
MGI ID:	MGI:3586329
Synonyms:	Fxyd2-
Gene:	Fxyd2  Location: Chr9:45311007-45321576 bp, + strand  Genetic Position: Chr9, 24.84 cM, cytoband B
Alliance:	Fxyd2tm1Kdr page

Germline Transmission:	Earliest citation of germline transmission: J:99929
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of exon 4, encoding most of the transmembrane domain, was replaced with a neomycin resistance gene and a lacZ gene. Absense of gamma subunits in mutants was confirmed by Western blot. (J:99929)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fxyd2 Mutation:	11 strains or lines available

Original:	J:99929 Jones DH, et al., Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem. 2005 May 13;280(19):19003-11
All:	4 reference(s)