Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Adam22tm1Sag Name: a disintegrin and metallopeptidase domain 22; targeted mutation 1, Koji Sagane MGI ID: MGI:3584137 Gene: Adam22  Location: Chr5:8122352-8418160 bp, - strand  Genetic Position: Chr5, 3.39 cM Alliance: Adam22tm1Sag page

Uncoordinated movements in Adam22tm1Sag/Adam22tm1Sag mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:99692
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A termination codon and neomycin resistance cassette were inserted into exon 8 in the pro-protein domain. Western blot using antisera to the cytoplasmic domain failed to detect mature protein. (J:99692)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adam22 Mutation:	72 strains or lines available

Original:	J:99692 Sagane K, et al., Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neurosci. 2005 May 6;6(1):33
All:	4 reference(s)