Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Frs2tm3Scl
Name:	fibroblast growth factor receptor substrate 2; targeted mutation 3, J Schlessinger
MGI ID:	MGI:3580390
Synonyms:	Frs2a-
Gene:	Frs2  Location: Chr10:116905332-116984439 bp, - strand  Genetic Position: Chr10, 65.09 cM
Alliance:	Frs2tm3Scl page

Germline Transmission:	Earliest citation of germline transmission: J:98901
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed such that a 0.5 kb fragment containing sequence encoding the first 22 amino acids, the first coding exon, was replaced by an IRES Beta-galactosidase neomycin resistance cassette. (J:98901)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frs2 Mutation:	64 strains or lines available

Original:	J:98901 Hadari YR, et al., Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8578-83
All:	3 reference(s)