Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mbl2tm1Kata
Name:	mannose-binding lectin (protein C) 2; targeted mutation 1, Kazue Takahashi
MGI ID:	MGI:3577339
Synonyms:	MBL-C KO
Gene:	Mbl2  Location: Chr19:30210342-30217087 bp, + strand  Genetic Position: Chr19, 25.14 cM
Alliance:	Mbl2tm1Kata page

Germline Transmission:	Earliest citation of germline transmission: J:98124
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by the insertion of a neomycin resistance gene into exon 6. RT-PCR analysis demonstrated the lack of transcript in mutant liver. (J:98124)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbl2 Mutation:	18 strains or lines available

Original:	J:98124 Shi L, et al., Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med. 2004 May 17;199(10):1379-90
All:	58 reference(s)