Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Alms1Gt(XH152)Byg
Name:	ALMS1, centrosome and basal body associated; gene trap XH152, BayGenomics
MGI ID:	MGI:3576051
Synonyms:	Alms1-, Alms1Gt(pGT1Lxf)1Pjn
Gene:	Alms1  Location: Chr6:85564513-85679735 bp, + strand  Genetic Position: Chr6, 37.48 cM
Alliance:	Alms1Gt(XH152)Byg page

Mutant Cell Line:	XH152
Germline Transmission:	Earliest citation of germline transmission: J:100403
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Hypomorph) Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap   Mutation details: A gene trap vector (pGT1Lxf) containing a splice acceptor, lacZ and neomycin resistance gene was inserted into intron 13. RT-PCR showed strong expression upstream of the inserted cassette, however, expression downstream of exon 13 was not detected in mutants. Slight traces of normally spliced exon 13-14 were detected in mutants, suggesting the disruption might have resulted in a hypomorphic allele. (J:100403) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select XH152 CC199534 (MGI Seq Detail) 5' RACE Chr6:85618480-85628396 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 7 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alms1 Mutation:	149 strains or lines available

Original:	J:100403 Collin GB, et al., Alms1-disrupted mice recapitulate human Alstrom syndrome. Hum Mol Genet. 2005 Aug 15;14(16):2323-33
All:	8 reference(s)