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Gene Expression Data
Assay Details
Assay
Reference: J:84449 Meunier D, et al., Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice. Dev Dyn. 2003 Jul;227(3):367-78
Assay type: RNA in situ
MGI Accession ID: MGI:3575918
Gene symbol: Nkx2-1
Gene name: NK2 homeobox 1
Probe: Nkx2.1 cDNA3
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 2c: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: thyroid gland Present Regionally restricted 2c Expression is in the ultimobranchial bodies and in the thyroid follicular precursors.
TS20: trachea epithelium Present 2c

Specimen 4a, wt: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: thyroid primordium Present 4a

Specimen 4b, -/-: embryonic day 9.5; Hoxa5tm1Rob/Hoxa5tm1Rob (more )
Structure Level Pattern Image Note
TS15: thyroid primordium Weak 4b Expression in this mutant is reduced by 30%.

Specimen 4c, wt: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: thyroid gland Present 4c

Specimen 4d, -/-: embryonic day 14.5; Hoxa5tm1Rob/Hoxa5tm1Rob (more )
Structure Level Pattern Image Note
TS22: thyroid gland Present 4d Expression in this mutant is the same as in wild-type embryos.

Specimen 4e, wt: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thyroid gland Present 4e

Specimen 4f, -/-: embryonic day 18.5; Hoxa5tm1Rob/Hoxa5tm1Rob (more )
Structure Level Pattern Image Note
TS26: thyroid gland Present 4f Expression in this mutant is the same as in wild-type embryos.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory