Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zic5tm1Sia
Name:	zinc finger protein of the cerebellum 5; targeted mutation 1, Shinichi Aizawa
MGI ID:	MGI:3574814
Synonyms:	Opr-
Gene:	Zic5  Location: Chr14:122696572-122703127 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Alliance:	Zic5tm1Sia page

Germline Transmission:	Earliest citation of germline transmission: J:97076
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A sequence 172 bp upstream of the zinc finger motif at exon 1 was replaced with a cassette containing stop-IRES-lacZ-loxP-neo-loxP. RT-PCR of mutant embryos confirmed absence of transcript. Crossing with EIIa-cre mice removed the neo. (J:97076)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:	36 strains or lines available

Original:	J:97076 Furushima K, et al., Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn. 2005 Apr;232(4):1056-61
All:	2 reference(s)