Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Trpv3tm1Apat
Name:	transient receptor potential cation channel, subfamily V, member 3; targeted mutation 1, Ardem Patapoutian
MGI ID:	MGI:3574024
Synonyms:	TRPV3-
Gene:	Trpv3  Location: Chr11:73158315-73191194 bp, + strand  Genetic Position: Chr11, 45.25 cM
Alliance:	Trpv3tm1Apat page

Germline Transmission:	Earliest citation of germline transmission: J:96549
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The exons encoding the putative pore region and adjacent transmembrane segments five and six were deleted by homologous recombination. RT-PCR of skin demonstrated that mutants lacked the wild-type protein. Presence of low levels of a truncated transcript was shown. (J:96549)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpv3 Mutation:	54 strains or lines available

Original:	J:96549 Moqrich A, et al., Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science. 2005 Mar 4;307(5714):1468-72
All:	19 reference(s)