Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Isl1tm1(cre/Esr1*)Krc
Name:	ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Kenneth R Chien
MGI ID:	MGI:3530632
Synonyms:	isl1-MCM, isl1-mER-Cre-mER, isl1-MerCreMer, Isl1tm1(cre/Esr1)Krc, MerCreMer
Gene:	Isl1  Location: Chr13:116434817-116446225 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Alliance:	Isl1tm1(cre/Esr1*)Krc page

Germline Transmission:	Earliest citation of germline transmission: J:96092
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Isl1tm1(cre/Esr1*)Krc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Isl1 (MGI:101791)   Mutation details: A targeting cassette containing a tamoxifen-dependent cre flanked by two mutated mouse estrogen receptors that sequester cre to the cytoplasm, followed by an FRT-flanked neo was inserted into the Isl1 locus by homologous recombination. Flp-mediated recombination removed the FRT-flanked neo cassette. A short segment of coding region containing the endogenous ATG codon was deleted. (J:96092, J:156167)

Activity:	Tissue activity of this recombinase allele
Driver:	Isl1 (mouse) Summary of all recombinase alleles driven by Isl1. Comparative matrix view of recombinase activities Alliance mouse Isl1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:	33 strains or lines available

Original:	J:96092 Laugwitz KL, et al., Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10;433(7026):647-53
All:	22 reference(s)