Tg(Prnp-SNCA)22Dpr Transgene Detail MGI Mouse (MGI:3530087)

Tg(Prnp-SNCA)22Dpr
Transgene Detail

Summary

Symbol:	Tg(Prnp-SNCA)22Dpr
Name:	transgene insertion 22, Donald L Price
MGI ID:	MGI:3530087
Synonyms:	Hualpha-Syn(WT), I2-2, MoPrP-Hualpha-Syn(WT)
Transgene:	Tg(Prnp-SNCA)22Dpr Location: unknown
Alliance:	Tg(Prnp-SNCA)22Dpr page

Transgene
origin

Strain of Origin:

(C3H/HeJ x C57BL/6J)F1

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(Prnp-SNCA)22Dpr expresses 1 gene

The transgene contains a wild-type human alpha synuclein cDNA and the murine prion promoter. (J:77344)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This line was originally designated I2-2. Transgenic mice express high levels of the human protein in the brain, but do not develop neurological abnormalities at any age. These mice do not show obvious abnormal accumulation of human alpha synuclein or ubiquitin.

References

Original:	J:77344 Lee MK, et al., Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73
All:	12 reference(s)

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