Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Atrxtm1Rjg
Name:	ATRX, chromatin remodeler; targeted mutation 1, Richard Gibbons
MGI ID:	MGI:3528480
Synonyms:	AtrxFl, Atrxflox, AtrxloxP, Atrxtm1Pick
Gene:	Atrx  Location: ChrX:104841221-104972978 bp, - strand  Genetic Position: ChrX, 47.26 cM
Alliance:	Atrxtm1Rjg page

Germline Transmission:	Earliest citation of germline transmission: J:95953
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo was inserted into intron 17 and a loxP sites into intron 18. Excision of this exon would still allow production of the shorter isoform containing exons 1-11. (J:95953, J:115836)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Atrxtm1Rjg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atrx Mutation:	78 strains or lines available

Original:	J:95953 Berube NG, et al., The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest. 2005 Feb;115(2):258-67
All:	34 reference(s)