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Gene Expression Data
Assay Details
Assay
Reference: J:59925 Miner JH, et al., Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol. 2000 Jan 15;217(2):278-89
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3528021
Gene symbol: Lama1
Gene name: laminin, alpha 1
Antibody: mAb 8B3
Detection system: Secondary antibody
Assay notes: Embryos were not fixed prior to sectioning. Authors state that sections were then sometimes fixed in acetone, ethanol or 2% paraformaldehyde.
Results
Specimen 1B: embryonic day 10.75 (more )
Structure Level Pattern Image Note
TS18: nephric duct Present Regionally restricted 1B Authors report that expression colocalized with laminin [a]5; expression in basement membranes associated with the Wollfian duct and recently branched ureteric bud.
TS18: ureteric bud Present Regionally restricted 1B Authors report that expression colocalized with laminin [a]5; expression in basement membranes associated with the Wollfian duct and recently branched ureteric bud.

Specimen 6A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 6A Authors report that laminin [a]1 has been properly eliminated from capillary loop stage glomerular basement membrane.

Specimen 6C: embryonic day 16.5; Lama5tm1Jhm/Lama5tm1Jhm (more )
Structure Level Pattern Image Note
TS24: maturing glomerular tuft Present Regionally restricted 6C Authors report that laminin [a]1 has been properly eliminated from capillary loop stage glomerular basement membrane.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory