Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akr1c18tm1Jni
Name:	aldo-keto reductase family 1, member C18; targeted mutation 1, James N Ihle
MGI ID:	MGI:3527218
Synonyms:	20alpha-HSD-
Gene:	Akr1c18  Location: Chr13:4182614-4200645 bp, - strand  Genetic Position: Chr13, 2.31 cM
Alliance:	Akr1c18tm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:95560
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3, encoding essential components of the enzyme's active site, were replaced with a neo in reverse transcription orientation. Western blot of mutant adrenal, kidney and ovary confirmed the lack of protein. (J:95560)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akr1c18 Mutation:	29 strains or lines available

Original:	J:95560 Piekorz RP, et al., Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. Mol Endocrinol. 2005 Feb;19(2):431-40
All:	2 reference(s)