Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drd1tm2Rpa
Name:	dopamine receptor D1; targeted mutation 1, Richard D Palmiter
MGI ID:	MGI:3527157
Synonyms:	D1R-NR1m, Drd1adnNR1, Drd1aGrin1-N616R
Gene:	Drd1  Location: Chr13:54205202-54209677 bp, - strand  Genetic Position: Chr13, 28.4 cM
Alliance:	Drd1tm2Rpa page

Germline Transmission:	Earliest citation of germline transmission: J:121750
Parent Cell Line:	v6.4 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S4/SvJae)F1

Allele Type:    Targeted (Dominant negative) Mutation:    Insertion   Mutation details: A cDNA open reading frame encoding a dominant-negative mutant NR1 subunit of the NMDA receptor with an asparagine-to-arginine substitution at amino acid 616 (N616R), a hemagglutinin (HA) epitope tag 27 aa from the N terminus and a polyadenylation signal, followed by a loxP-flanked SV40-neo cassette, has replaced the first ~130 base pairs of the endogenous Drd1a gene. (J:121750)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd1 Mutation:	68 strains or lines available

Original:	J:121750 Heusner CL, et al., Expression of mutant NMDA receptors in dopamine D1 receptor-containing cells prevents cocaine sensitization and decreases cocaine preference. J Neurosci. 2005 Jul 13;25(28):6651-7
All:	2 reference(s)