Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Rai1tm1Jrl
Name:	retinoic acid induced 1; targeted mutation 1, James R Lupski
MGI ID:	MGI:3526160
Synonyms:	Rai1-
Gene:	Rai1  Location: Chr11:59995839-60090023 bp, + strand  Genetic Position: Chr11, 37.81 cM, cytoband B2
Alliance:	Rai1tm1Jrl page

Germline Transmission:	Earliest citation of germline transmission: J:98073
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An approximately 4.0 kb of the coding region in exon 2 was replaced by an intra-ribosomal entry site IRES-lacZ-pA cassette followed by a loxP flanked PGKneobpA cassette. RT-PCR indicated that only sequence 5' of the deleted region was present in transcripts. This truncation eliminates all nuclear localization regions and the PHD domain. (J:98073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	65 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rai1 Mutation:	73 strains or lines available

Original:	J:98073 Bi W, et al., Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Hum Mol Genet. 2005 Apr 15;14(8):983-95
All:	10 reference(s)