Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Btg2tm1Spo
Name:	BTG anti-proliferation factor 2; targeted mutation 1, S Paul Oh
MGI ID:	MGI:3525505
Synonyms:	Btg2-, PC3/Tis21-
Gene:	Btg2  Location: Chr1:134002908-134006858 bp, - strand  Genetic Position: Chr1, 58.1 cM
Alliance:	Btg2tm1Spo page

Germline Transmission:	Earliest citation of germline transmission: J:95124
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced exon 2, which contains sequence encoding APRO homology boxes A and B. Northern blot demonstrated the lack of transcript in mutant kidney samples. (J:95124)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Btg2tm1Spo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btg2 Mutation:	14 strains or lines available

Original:	J:95124 Park S, et al., B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol. 2004 Dec;24(23):10256-62
All:	9 reference(s)