Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Npr2tm1Gar Name: natriuretic peptide receptor 2; targeted mutation 1, David L Garbers MGI ID: MGI:3522129 Synonyms: Npr2- Gene: Npr2  Location: Chr4:43631935-43651244 bp, + strand  Genetic Position: Chr4, 23.05 cM Alliance: Npr2tm1Gar page

Skeletal comparison of wild type and Npr2tm1Gar/Npr2tm1Gar mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:94718
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3-7, which encode the C-terminal half of the extracellular ligand-binding domain and the transmembrane segment, were replaced with a neo. mRNA was not detected in brains of mutant animals. (J:94718)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npr2 Mutation:	61 strains or lines available

Original:	J:94718 Tamura N, et al., Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17300-5
All:	4 reference(s)