Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hand1tm2Eno
Name:	heart and neural crest derivatives expressed 1; targeted mutation 2, Eric N Olson
MGI ID:	MGI:3514024
Synonyms:	Hand1fx
Gene:	Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Alliance:	Hand1tm2Eno page

Germline Transmission:	Earliest citation of germline transmission: J:94514
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The first exon was flanked with loxP sites via homologous recombination. An upstream FRT-flanked neo resistance cassette was removed by crossing with Tg(ACTFLPe)9205Dym transgenic mice. (J:94514)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	54 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	21 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:	14 strains or lines available

Original:	J:94514 McFadden DG, et al., The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan;132(1):189-201
All:	9 reference(s)