Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pank2tm1Jgt
Name:	pantothenate kinase 2; targeted mutation 1, Jane Gitschier
MGI ID:	MGI:3514020
Synonyms:	Pank2-
Gene:	Pank2  Location: Chr2:131104415-131141108 bp, + strand  Genetic Position: Chr2, 63.31 cM
Alliance:	Pank2tm1Jgt page

Germline Transmission:	Earliest citation of germline transmission: J:94753
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.3 kb fragment containing half of exon 2 and part of intron 2 was replaced with a lacZ and neomycin resistance cassette driven by the polII promoter. RT-PCR and Western blot analysis confirmed the absence of transcription and translation products. (J:94753)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pank2 Mutation:	34 strains or lines available

Original:	J:94753 Kuo YM, et al., Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. Hum Mol Genet. 2005 Jan 1;14(1):49-57
All:	4 reference(s)