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Mad2l2repro22
Chemically induced Allele Detail
Summary
Symbol: Mad2l2repro22
Name: MAD2 mitotic arrest deficient-like 2; reproductive mutant 22, JAX Reproductive Mutagenesis Program
MGI ID: MGI:3512941
Synonyms: G1-453-4, Rev7C70R
Gene: Mad2l2  Location: Chr4:148214841-148230156 bp, + strand  Genetic Position: Chr4, 78.67 cM, cytoband E1
Alliance: Mad2l2repro22 page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of arginine for cysteine at position 70 (C70R). (J:209515)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mad2l2 Mutation:  14 strains or lines available
Notes
Males and females are infertile: very low testis weight, no epididymal sperm are recovered. In females, no oocytes recovered. Histological analysis shows germ cell depletion; spermatogonia are present but not later spermatogenic stages. Ovaries are tiny.
References
Original:  J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7;
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory