Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grin3btm1Yaha
Name:	glutamate receptor, ionotropic, NMDA3B; targeted mutation 1, Yasunori Hayashi
MGI ID:	MGI:3512173
Synonyms:	NR3B-
Gene:	Grin3b  Location: Chr10:79806549-79813024 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Grin3btm1Yaha page

Germline Transmission:	Earliest citation of germline transmission: J:126239
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, which contains the initiation codon and sequences encoding the signal peptide, was replaced with a loxP-flanked neomycin selection cassette. The selection cassette was removed through Cre-mediated recombination, leaving a single loxP site in place of exon 1. RT-PCR and in situ hybridization analysis confirmed that no detectable transcript is expressed from this allele. (J:126239)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin3b Mutation:	36 strains or lines available

Original:	J:126239 Niemann S, et al., Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. Eur J Neurosci. 2007 Sep;26(6):1407-20
All:	1 reference(s)