Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fgf23tm1Blan
Name:	fibroblast growth factor 23; targeted mutation 1, Beate Lanske
MGI ID:	MGI:3512143
Synonyms:	Fgf-23-
Gene:	Fgf23  Location: Chr6:127049865-127058371 bp, + strand  Genetic Position: Chr6, 61.92 cM
Alliance:	Fgf23tm1Blan page

Germline Transmission:	Earliest citation of germline transmission: J:94041
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-3 were replaced with lacZ and a neomycin resistance gene. LacZ was cloned in frame downstream of the endogenous initiator methionine. Staining of embryos indicates the mutant gene was expressed in heterozygotes. (J:94041)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf23 Mutation:	16 strains or lines available

Original:	J:94041 Sitara D, et al., Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004 Nov;23(7):421-32
All:	34 reference(s)