Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Timp1tm1Pds
Name:	tissue inhibitor of metalloproteinase 1; targeted mutation 1, Paul D Soloway
MGI ID:	MGI:3512125
Synonyms:	Timp1-, TIMP-1-, TIMP1KO, TIMP-1KO, Timp1tm1Jae
Gene:	Timp1  Location: ChrX:20736405-20740974 bp, + strand  Genetic Position: ChrX, 16.38 cM
Alliance:	Timp1tm1Pds page

Germline Transmission:	Earliest citation of germline transmission: J:43744
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin-thymidine kinase expression cassette resulted in a duplication of part of the gene (the second through the fifth coding exons, with the duplicated copies separated by the selectable markers), and inserted into the third coding exon a 21 bp sequence that placed a stop codon in each reading frame. Northern blot analyses failed to detect transcripts from this allele in lung, ovaries or embryonic fibroblasts. (J:43744, J:94836)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Timp1 Mutation:	12 strains or lines available

Original:	J:43744 Soloway PD, et al., Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. 1996 Dec 5;13(11):2307-14
All:	68 reference(s)