Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sufutm1Aeb
Name:	SUFU negative regulator of hedgehog signaling; targeted mutation 1, Allen E Bale
MGI ID:	MGI:3512046
Gene:	Sufu  Location: Chr19:46385335-46477243 bp, + strand  Genetic Position: Chr19, 38.85 cM
Alliance:	Sufutm1Aeb page

Germline Transmission:	Earliest citation of germline transmission: J:101731
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Vector contains exon 4 through the 3' end of intron 6 then PGK-driven NEO in orientation reverse to the gene followed by the 3' end of exon 7 through the end of exon 8. Correct targeting replaces the intron 6/exon 7 splice site and a portion of exon 7 with the neo casette. Northern and Western blot analysis confirmed the absence of transcription and translation. (J:101731)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sufu Mutation:	59 strains or lines available

Original:	J:101731 Cooper AF, et al., Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development. 2005 Oct;132(19):4407-17
All:	1 reference(s)