Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ppargc1atm1Brsp Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Bruce M Spiegelman MGI ID: MGI:3511352 Synonyms: PGC-1alpha- Gene: Ppargc1a  Location: Chr5:51611592-51725068 bp, - strand  Genetic Position: Chr5, 27.02 cM, cytoband C1 Alliance: Ppargc1atm1Brsp page

Ppargc1atm1Brsp/Ppargc1atm1Brsp mice develop dilated cardiomyopathy in response to transverse aortic constriciton (TAC) Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:93896
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele resulted from the crossing of Ppargc1atm2Brsp with mice expressing cre recombinase in the germline. Exons 3-5 were removed from the locus. Northern and Western blot analyses indicated a lack of transcript and protein in mutants. (J:93896)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppargc1a Mutation:	47 strains or lines available

Original:	J:93896 Lin J, et al., Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1):121-35
All:	89 reference(s)