Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cops5tm1Jka
Name:	COP9 signalosome subunit 5; targeted mutation 1, Jun-ya Kato
MGI ID:	MGI:3511260
Synonyms:	Jab1-
Gene:	Cops5  Location: Chr1:10094825-10108384 bp, - strand  Genetic Position: Chr1, 2.29 cM
Alliance:	Cops5tm1Jka page

Germline Transmission:	Earliest citation of germline transmission: J:93979
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neo marker gene replaced exons 1-6, including the start codon, via homologous recombination. Western analysis using an antibody that recognized the C terminus did not detect truncated polypeptides from the putative open reading frame in exons 7 and 8. (J:93979)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cops5 Mutation:	23 strains or lines available

Original:	J:93979 Tomoda K, et al., Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004 Oct 8;279(41):43013-8
All:	3 reference(s)