Summary | Transgene origin | Transgene description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Ela1-TAg*)289Mjt
Name:	transgene insertion 289, Mary J Tevethia
MGI ID:	MGI:3510408
Synonyms:	T1-147
Transgene:	Tg(Ela1-TAg*)289Mjt  Location: unknown
Alliance:	Tg(Ela1-TAg*)289Mjt page

Strain of Origin:

(B6D2F1/J x C57BL/6)

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Mutation details: The E1-T147 transgene was designed with a 4.3 kb rat elastase 1 (Ela1 or E1) gene upstream control region, LTR stabilizer, and SV40 late 16S splice site all upstream of the simian virus 40 large T antigen (TAg) coding sequence for amino acids 1-147 (with stop codon introduced at amino acid 148) and polyA sequence. The T1-147 transgenic mice (founder line 289) mice were established. (J:78026)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Ela1-TAg*)289Mjt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:78026 Tevethia MJ, et al., A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol. 1997 Nov;71(11):8157-66
All:	3 reference(s)