Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Pcp2-SCA2)11Plt
Name:	transgene insertion 11, Stefan M Pulst
MGI ID:	MGI:3505741
Synonyms:	Q58-11, Tg(Pcp2SCA2)11Plt
Transgene:	Tg(Pcp2-SCA2)11Plt  Location: unknown
Alliance:	Tg(Pcp2-SCA2)11Plt page

Strain of Origin:

(C57BL/6J x DBA/2J)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Pcp2-SCA2)11Plt expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human ATXN2 (6311) Atxn2  (MGI:1277223)   Mutation details: The transgene contains a full length human spinocerebellar ataxia 2 (SCA2) cDNA (with a 58 CAG repeat) as well as the mouse Pcp2 (Purkinje cell protein 2) promoter, untranslated, and poly(A) sequences. Transcripts and protein product are detected in the cerebellum. (J:93869)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:93869 Huynh DP, et al., Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet. 2000 Sep;26(1):44-50
All:	4 reference(s)