Tg(TcrbAI4)1Dvs Transgene Detail MGI Mouse (MGI:3057181)

Tg(TcrbAI4)1Dvs
Transgene Detail

Summary

Symbol:	Tg(TcrbAI4)1Dvs
Name:	transgene insertion 1, David V Serreze
MGI ID:	MGI:3057181
Synonyms:	AI4bTg
Transgene:	Tg(TcrbAI4)1Dvs Location: unknown
Alliance:	Tg(TcrbAI4)1Dvs page

Transgene
origin

Strain of Origin:

NOD/ShiLt

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(TcrbAI4)1Dvs expresses 1 gene

Mutation details: The rearranged Tcrb transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgenic construct contains a Tcrb-V2/Tcrb-D/Tcrb-J cDNA segment. (J:93553)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available

Notes

In conjunction with Rag1^tm1Mom

transgenic mice carrying both the alpha and beta AI4 TCR transgenes exhibit an accelerated development of insulin-dependent diabetes mellitus (IDDM).

homozygous mice are viable and fertile

References

Original:	J:93553 Graser RT, et al., Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol. 2000 Apr 1;164(7):3913-8
All:	14 reference(s)

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