Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Igk-C/Igk-V125)1Jwt
Name:	transgene insertion 1, James W Thomas
MGI ID:	MGI:3057119
Synonyms:	VK125, VK125-Ck, Vk125Tg, Vkappa125Tg
Transgene:	Tg(Igk-C/Igk-V125)1Jwt  Location: unknown
Alliance:	Tg(Igk-C/Igk-V125)1Jwt page

Strain of Origin:

(C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Igk-C/Igk-V125)1Jwt expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ighg1 (MGI:96446)   Mutation details: The transgene encodes a light chain that, when co-expressed with a transgene encoding the heavy chain with the VDJ of mAB125, binds most mammalian insulins. The source of the immunoglobulin kappa chain VJ sequence in this transgene was the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 (from the American Type Culture Collection). (J:91865)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:91865 Hulbert C, et al., B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol. 2001 Nov 15;167(10):5535-8
All:	7 reference(s)