Tg(LCK-NFKBIA)5Dwb
Transgene Detail
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| Symbol: |
Tg(LCK-NFKBIA)5Dwb |
| Name: |
transgene insertion 5, Dean W Ballard |
| MGI ID: |
MGI:3056807 |
| Synonyms: |
IkappaBalpha(deltaN), IkappaNalphadeltaN-Tg, LCK |
| Transgene: |
Tg(LCK-NFKBIA)5Dwb Location: unknown
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| Alliance: |
Tg(LCK-NFKBIA)5Dwb page
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| Strain of Origin: |
C57BL/6 x DBA/2
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| Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(LCK-NFKBIA)5Dwb expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
NFKBIA (4792) |
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Mutation details: An amino acid-truncated human NFKBIA gene (coding for amino acids 37-317) fused to a FLAG epitope was placed under the control of a human LCK promoter. The protein encoded by this transgene lacks sequences required for signal-dependent degradation and functions as a constitutive repressor of multiple NK-kappaB pathways. Transgene expression was readily detected in the thymus and spleen as determined by immunoblot analysis.
(J:93003)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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| Original: |
J:93003 Boothby MR, et al., Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med. 1997 Jun 2;185(11):1897-907 |
| All: |
18 reference(s) |
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Analysis Tools
