Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(FCGR2A)11Mkz
Name:	transgene insertion 11, Steven E McKenzie
MGI ID:	MGI:3056729
Synonyms:	FcgammaRIIATGN, huFCGR2AR131
Transgene:	Tg(FCGR2A)11Mkz  Location: unknown
Alliance:	Tg(FCGR2A)11Mkz page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(FCGR2A)11Mkz expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human FCGR2A (2212) Fcgr2b  (MGI:95499) Fcgr3  (MGI:95500)   Mutation details: The transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R131 polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells. (J:93244, J:136516)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:93244 McKenzie SE, et al., The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 May 1;162(7):4311-8
All:	42 reference(s)