Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Alcamtm1Jawe
Name:	activated leukocyte cell adhesion molecule; targeted mutation 1, Joshua A Weiner
MGI ID:	MGI:3056579
Synonyms:	BEN-
Gene:	Alcam  Location: Chr16:52069359-52273444 bp, - strand  Genetic Position: Chr16, 32.88 cM, cytoband B5
Alliance:	Alcamtm1Jawe page

Germline Transmission:	Earliest citation of germline transmission: J:93205
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced by EGFP and loxP flanked neo via homologous recombination. Neo was removed via cre mediated recombination of the flanking loxP sites, resulting in increased GFP expression. Northern and immunohistochemical analysis confirmed the absence of RNA in adult brain and protein in E12 spinal cords. (J:93205)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Alcam Mutation:	39 strains or lines available

Original:	J:93205 Weiner JA, et al., Axon fasciculation defects and retinal dysplasias in mice lacking the immunoglobulin superfamily adhesion molecule BEN/ALCAM/SC1. Mol Cell Neurosci. 2004 Sep;27(1):59-69
All:	18 reference(s)