Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(CD8aCD8b)57Scr
Name:	transgene insertion 57, The Scripps Research Institute
MGI ID:	MGI:3055355
Transgene:	Tg(CD8aCD8b)57Scr  Location: unknown
Alliance:	Tg(CD8aCD8b)57Scr page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(CD8aCD8b)57Scr expresses 2 genes Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human CD8A (925) Cd8a  (MGI:88346) human CD8B (926) Cd8b1  (MGI:88347)   Mutation details: The transgene contains the human CD8 alpha and beta chain genes driven by the T cell-specific Lck promoter. CD8alpha-alpha homodimers were expressed on 62% of thymocytes and CD8alpha-beta heterodimers on 14% of thymocytes. Peripheral T cells preferentially expressed the CD8alpha-beta heterodimers at a 4:1 ratio. Human CD8alpha was detected on both CD4+ and CD8+ T cells. (J:92994)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:92994 LaFace DM, et al., Human CD8 transgene regulation of HLA recognition by murine T cells. J Exp Med. 1995 Nov 1;182(5):1315-25
All:	2 reference(s)