Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(TCRA)B1Jg
Name:	transgene insertion B1, Joan M Goverman
MGI ID:	MGI:3055333
Transgene:	Tg(TCRA)B1Jg  Location: unknown
Alliance:	Tg(TCRA)B1Jg page

Strain of Origin:

C57BL/6 x DBA/2

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(TCRA)B1Jg expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Tcra (MGI:98553)   Mutation details: A functionally rearranged Tcra gene was used in the construction of this transgene. A recombined Tcra gene with Valpha2.3 and JalphaTA39 gene segments was cloned from the B10.PL hybridoma "172.10". This hybridoma was specific for the 11 amino-terminal residues of myelin basic protein (MBP). Crossing this line with the Tg(TCRB)C14Jg line produces a T cell with a transgenic TCR that has high affinity for the first 11 amino acids of MBP. In these doubly transgenic mice, 50-95% of CD3+ cells expressed the transgenic Tcra gene. (J:92991)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:92991 Goverman J, et al., Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993 Feb 26;72(4):551-60
All:	15 reference(s)