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Cd83lcd4
Chemically induced Allele Detail
Summary
Symbol: Cd83lcd4
Name: CD83 antigen; low CD4 cell
MGI ID: MGI:3055293
Synonyms: CD83mu, LCD4.1
Gene: Cd83  Location: Chr13:43938588-43956609 bp, + strand  Genetic Position: Chr13, 21.6 cM, cytoband A4-5
Alliance: Cd83lcd4 page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe last exon contains a missense mutation that changes the stop codon to an arginine, extending the protein by 55 amino acids. Immunohistochemistry was unable to detect protein expression and Western blot revealed a severe reduction in the amount of protein. (J:92721)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd83 Mutation:  15 strains or lines available
References
Original:  J:92721 Garcia-Martinez LF, et al., A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J Immunol. 2004 Sep 1;173(5):2995-3001
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory