Tg(DBHn-lacZ)8Rpk Transgene Detail MGI Mouse (MGI:3055106)

Tg(DBHn-lacZ)8Rpk
Transgene Detail

Summary

Symbol:	Tg(DBHn-lacZ)8Rpk
Name:	transgene insertion 8, Raj P Kapur
MGI ID:	MGI:3055106
Synonyms:	DBH-lacZ, DBH-nlacZ(2860-8)
Transgene:	Tg(DBHn-lacZ)8Rpk Location: unknown
Alliance:	Tg(DBHn-lacZ)8Rpk page

Transgene
origin

Strain of Origin:

C57BL/6 x SJL

Transgene
description

Transgene Type:		Transgenic (Reporter)
Mutation:		Insertion
		Mutation details: A fragment of the human dopamine beta hydroxylase (DBH) gene, extending from a Sma1 site 5.8 kb upstream from the transcription start to an HpaII site 41 bp into the 5' untranslated region of exon 1, was fused to a bacterial beta-galactosidase reporter gene. (J:92929)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line was generated from founder 2860-8.

LacZ expression is seen in neurons of the locus ceruleus and other classic noradrenergic brain stem nuclei, sympathetic ganglion neurons, and adrenal chromaffin cells. LacZ expression is also observed in neurons of the enteric system, the retina, some sensory and all cranial parasympathetic ganglia, and some diencephalic and telencephalic brain nuclei.

References

Original:	J:92929 Mercer EH, et al., The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron. 1991 Nov;7(5):703-16
All:	6 reference(s)

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