Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkcitm1Hed
Name:	protein kinase C, iota; targeted mutation 1, Stephen M Hedrick
MGI ID:	MGI:3054940
Synonyms:	PKClamda-
Gene:	Prkci  Location: Chr3:31049893-31106889 bp, + strand  Genetic Position: Chr3, 14.65 cM
Alliance:	Prkcitm1Hed page

Germline Transmission:	Earliest citation of germline transmission: J:92719
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 9 and intron 9, containing the ATP binding site and the splice acceptor site for exon 10, were replaced with a PGK-neobpA cassette in the opposite transcriptional orientation. RT-PCR from day 7.5 mutant embryos showed there was no transcript. (J:92719)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkci Mutation:	69 strains or lines available

Original:	J:92719 Soloff RS, et al., Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 1;173(5):3250-60
All:	2 reference(s)