Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rxfp1tm1Aia
Name:	relaxin/insulin-like family peptide receptor 1; targeted mutation 1, Alexander I Agoulnik
MGI ID:	MGI:3054831
Synonyms:	Lgr7-, Lgr7ko, Rfxp1-LacZ, Rxfp1TG
Gene:	Rxfp1  Location: Chr3:79548918-79645187 bp, - strand  Genetic Position: Chr3, 34.94 cM
Alliance:	Rxfp1tm1Aia page

Germline Transmission:	Earliest citation of germline transmission: J:92627
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to create a duplication of the sequence between parts of exons 15-17 and to insert the IRES-LacZ cassette into exon 17. RT-PCR of brain and testis failed to amplify the expected fragment of the distal part of exon 15, indicating the absence of correctly spliced transcripts. (J:92627)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxfp1 Mutation:	53 strains or lines available

Original:	J:92627 Kamat AA, et al., Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology. 2004 Oct;145(10):4712-20
All:	7 reference(s)