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Cdk6tm1Bbd
Targeted Allele Detail
Summary
Symbol: Cdk6tm1Bbd
Name: cyclin dependent kinase 6; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:3053975
Synonyms: Cdk6-
Gene: Cdk6  Location: Chr5:3391485-3581008 bp, + strand  Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
Alliance: Cdk6tm1Bbd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92529
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced the first coding exon, which contains the ATG as well as the PLSTIRE domain essential for cyclin binding. PCR confirmed recombination in mutant mice. Immunohistochemical analysis of lymphocytes indicated lack of protein expression in mutants. (J:92529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk6 Mutation:  39 strains or lines available
References
Original:  J:92529 Malumbres M, et al., Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 2004 Aug 20;118(4):493-504
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory