Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Gli1tm3(cre/ERT2)Alj
Name:	GLI-Kruppel family member GLI1; targeted mutation 3, Alexandra L Joyner
MGI ID:	MGI:3053957
Synonyms:	Gli1CreER, Gli1CreERT2, Gli1-CreERT2, Gli1tm3(cre/ERT2)Alj, Gli1tm3(cre/ESR1)Alj
Gene:	Gli1  Location: Chr10:127165751-127177448 bp, - strand  Genetic Position: Chr10, 74.5 cM
Alliance:	Gli1tm3(cre/ERT2)Alj page

Germline Transmission:	Earliest citation of germline transmission: J:92507
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gli1tm3(cre/ERT2)Alj expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gli1 (MGI:95727)   Mutation details: CreERT2 cDNA and a floxed neo were inserted into the 5' UTR of the first coding exon. Crossing with mice expressing Cre removed the floxed neo. Cre expression in mice carrying this allele is induced by treating the mice with tamoxifen. (J:92507)

Activity:	Tissue activity of this recombinase allele
Driver:	Gli1 (mouse) Summary of all recombinase alleles driven by Gli1. Comparative matrix view of recombinase activities Alliance mouse Gli1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Gli1tm3(cre/ERT2)Alj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gli1 Mutation:	48 strains or lines available

Original:	J:92507 Ahn S, et al., Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004 Aug 20;118(4):505-16
All:	190 reference(s)