Summary | Transgene origin | Transgene description | Find Mice (IMSR) | Notes | References

Symbol:	Tg(SOD1)10Cje
Name:	transgene insertion 10, Charles J Epstein
MGI ID:	MGI:3053950
Synonyms:	218/10, TgHS-218/10
Transgene:	Tg(SOD1)10Cje  Location: unknown
Alliance:	Tg(SOD1)10Cje page

Strain of Origin:

(C57BL/6J x SJL/J)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(SOD1)10Cje expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SOD1 (6647) Sod1  (MGI:98351)   Mutation details: The entire human SOD1 sequence was used for the transgene. Eight copies of the transgene inserted into Chromosome 10 (J:18645). Northern blot analysis of brain and liver from transgenic animals showed expression of 0.9 kb and 0.7 kb transcripts similar to that in humans. Transgenic animals exhibited increased enzyme activity in nearly all tissues examined. (J:30458)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:30458 Epstein CJ, et al., Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A. 1987 Nov;84(22):8044-8
All:	5 reference(s)