Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nototm1Gos
Name:	notochord homeobox; targeted mutation 1, Achim Gossler
MGI ID:	MGI:3053092
Synonyms:	NoteGFP, NotoGFP
Gene:	Noto  Location: Chr6:85400868-85405859 bp, + strand  Genetic Position: Chr6, 37.44 cM
Alliance:	Nototm1Gos page

Germline Transmission:	Earliest citation of germline transmission: J:91405
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An eGFP and floxed neo were inserted in frame into exon 1, deleting most of exon 1 and all of exon 2, thereby removing about 80% of the open reading frame, including the homeodomain. The floxed neo was excised by crossing mice with mice expressing cre in the germ line. PCR confirmed recombination in mutant mice. (J:91405)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	206 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Noto Mutation:	15 strains or lines available

Original:	J:91405 Abdelkhalek HB, et al., The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 2004 Jul 15;18(14):1725-36
All:	10 reference(s)