Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox2tm3Skn
Name:	SRY (sex determining region Y)-box 2; targeted mutation 3, Silvia K Nicolis
MGI ID:	MGI:3052123
Synonyms:	Sox2deltaENHdeltaneo
Gene:	Sox2  Location: Chr3:34704554-34706610 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Alliance:	Sox2tm3Skn page

Germline Transmission:	Earliest citation of germline transmission: J:92063
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed PGK-neo replaced an upstream neural cell-specific enhancer. Crossing with CMV-Cre mice excised the floxed neo, leaving a single loxP site. (J:92063)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:	56 strains or lines available

Original:	J:92063 Ferri AL, et al., Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development. 2004 Aug;131(15):3805-19
All:	3 reference(s)